Publications

            Selected Publications (click for complete and up-to-date list)

1. 1. 1. Wolford BN, Zhao Y, Surakka I, Wu KH, Yu X, Richter CE, Bhatta L, Brumpton B, Desch K, Thibord F, Klarin D, Johnson AD, Trégouët D, Damrauer SM, Smith NL, INVENT, MVP, Faro VL, Tsuo K, Global Biobank Meta-analysis Initiative (GBMI), Daly MJ, Neale B, Zhou W, *Shavit JA, and *Willer CJ. Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish. medRxiv, https://doi.org/10.1101/2022.06.21.22276721, 2022.
      2. Huang J, Sun C, Zhao NN, Shavit JA, Zhu Y, and Chen SX. Nuclear progesterone receptor regulates blood coagulation facilitating ovulation in zebrafish.  Endocrinology, 163:1-16, 2022.
      3. Zhou W…(~150 total authors)…Shavit JA…Willer CJ, Daly MJ, and Neale BM. Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseases. medRxiv, https://doi.org/10.1101/2021.11.19.21266436, 2021.
      4. Yee A, Dai M, Croteau SE, Shavit JA, Pipe SW, Siemieniak D, Meng F, and Ginsburg D.  Phage display broadly identifies inhibitor-reactive regions in von Willebrand factor. J Thromb Haemost, 19:2702-9, 2021.
      5. Bragazzi Cunha J, Elenbaas JS, Maitra D, Kuo N, Azuero-Dajud R, Ferguson AC, Griffin MS, Lentz SI, Shavit JA, and Omary MB.  Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models.  Sci Rep, 11:9601, 2021.
      6. Freire C, Fish RJ, Vilar R, Di Sanza C, Grzegorski SJ, Richter CE, Shavit JA, and Neerman-Arbez M.  A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis. Blood Adv, 4:5480-91, 2020.
      7. Bando H, Gergics P, Bohnsack BL, Toolan KP, Richer CE, Shavit JA, and Camper SA.  otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease.  Hum Mol Genet, 29:1648-57, 2020.
      8. Grzegorski, SJ, Hu Z, Liu Y, Yu X, Ferguson AC, Madarati H, Friedman AP, Reyon D, Kim PY, Kretz CA, Joung JK, and Shavit JA.  Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.  Sci Rep, 10:4049, 2020.
      9. Helms AS, Tang VT, O’Leary TS, Friedline S, Wauchope M, Arora A, Wasserman AH, Smith ED, Lee LM, Wen X, Shavit JA, Liu AP, Previs MJ, and Day SM.  Effects of MYBPC3 loss of function mutations preceding hypertrophic cardiomyopathy.  JCI Insight, 5:133782, 2020.
      10. Maitra D, Cunha JB, Elenbaas JS, Bonkovsky HL, Shavit JA, and Omary MB.  Porphyrin-induced protein oxidation and aggregation as a mechanism of porphyria associated cell injury.  Cell Mol Gastroenterol Hepatol, 8:535-48, 2019.
      11. Weyand AC, Grzegorski SJ, Rost MS, Lavik KI, Ferguson AC, Menegatti M, Richter CE, Asselta R, Duga S, Peyvandi F, and Shavit JA.  Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasis.  Blood Adv, 3:1670-80, 2019.
      12. Khoriaty R, Ozel AB, Ramdas S, Ross C, Desch K, Shavit JA, Everett L, Siemieniak D, Li JZ, Ginsburg D.  Genome-wide linkage analysis and whole-exome sequencing identifies an ITGA2B mutation in a family with thrombocytopenia.  Br J Haematol, 186:574-9, 2019.
      13. Thiessen KD, Grzegorski SJ, Higuchi L, Shavit JA, and Kramer KL.  Zebrafish otolith biomineralization requires polyketide synthase.  Mech Dev, 157:1-9, 2019.
      14. Hortle E, Johnson KE, Johansen MD, Nguyen T, Shavit JA, Britton WJ, Tobin DM, and Oehlers SH.  Thrombocyte inhibition restores protective immunity to mycobacterial infection.  J Infect Dis, 220:524-34, 2019.
      15. Hu Z, Lavik KI, Liu Y, Vo AH, Richter CE, Di Paola J, and Shavit JA.  Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia.  J Thromb Haemost, 17:607-17, 2019.
      16. Rost MS, Shestopalov I, Liu Y, Vo AH, Richter CE, Emly SM Barrett FG, Stachura DL, Holinstat M, Zon LI, and Shavit JA.  Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.  Blood Adv, 2:3418-27, 2018.
      17. Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W…(49 total authors)…Shavit JA…Stefansson K, Abecasis GR, Hveem K, and Willer CJ. Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.  Nat Genet, 50:1234-9, 2018.
      18. Hu Z, Liu Y, Huarng, MC, Menegatti M, Reyon D, Rost MS, Norris ZG, Richter CE, Stapleton AN, Chi NC, Peyvandi F, Joung JK, and Shavit JA.  Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.  Blood, 130:666-76, 2017.
      19. Williams LM, Lago BA, McArthur AG, Raphenya AR, Pray N, Saleem N, Salas S, Paulson K, Mangar RS, Liu Y, Vo AH, Shavit JA.  The transcription factor, nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development.  Aquat Toxicol, 180:141-154, 2016.
      20. Rost MS, Grzegorski SJ, and Shavit JA.  Quantitative methods for studying hemostasis in zebrafish larvae.  Methods Cell Biol, 134:377-89, 2016.
      21. Huarng, MC and Shavit JA.  Simple and rapid quantification of thrombocytes in zebrafish larvae.  Zebrafish, 12:238-42, 2015.
      22. Weyand, AC and Shavit JA.  Zebrafish as a model system for the study of hemostasis and thrombosis.  Curr Opin Hematol, 21:418-22, 2014.
      23. Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng, MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, and Shavit JA.  Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.  Blood, 124:142-50, 2014.
      24. Vo A, Swaroop A, Liu Y, Norris ZG, and Shavit JA.  Loss of fibrinogen in zebrafish results in symptoms consistent with human hypofibrinogenemia.  PLoS One, 8:e74682, 2013.
      25. Ghosh A, Vo A, Twiss BK, Kretz CA, Jozwiak MA, Montgomery RR, and Shavit JA.  Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage.  Adv Hematol, 2012:1-9, 2012.
      26. Chen X, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong T, Yu G, Ginsburg D, Toomre D, Xu Z, and Saltiel AR.  The function of the exocyst is regulated by effector phosphorylation.  Nat Cell Biol, 13:580-8, 2011.
      27. Shavit JA, Manichaikul, A, Lemmerhirt HL, Broman KW, and Ginsburg D.  Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice.  Blood, 114:5368-74, 2009.